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. 2012 Nov 14;109(3):742–748. doi: 10.1152/jn.00539.2012

Fig. 2.

Fig. 2.

Time course of pruritogen-elicited scratching. A: mean number of scratch bouts/5 min over the 30-min period following intradermal (id) pruritogen injection preceded by systemic injection of vehicle (saline; open circles), neurokinin-1 (NK-1) receptor antagonist L-733060 (10 mg/kg; filled circles), or GRP receptor antagonist RC-3095 (0.3 mg/kg; filled triangles). Error bars: SE; n = 6/group. B: as in A for BAM8-22. C: as in A for histamine. D: as in A for SLIGRL-NH2. E: as in A for 5-HT. *Significantly different from vehicle group; P < 0.05, post hoc Student-Newman-Keuls test, following 2-way repeated-measures ANOVA; F(10, 97) = 7.29; n = 6/group.