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. 2012 Nov 7;109(3):867–872. doi: 10.1152/jn.00886.2012

Fig. 3.

Fig. 3.

Nicotinic response is not due to activation of α7 or β2 subunit containing nAChRs. Responses from single cells. Black traces are control response and gray traces are after application of specific antagonists. A: response of a single progenitor cell is completely blocked by 5 μM mecamylamine (MEC). B: 10 nM MLA, an antagonist specific for α7nAChR, has no effect. C: further block by 10 μM DHBE (MLA+DHBE) also fails to block the calcium transient. D: response is present in progenitor cells from β2 nAChR knockout mice. Average response from 104 progenitor cells from 7 β2 nAChR knockout mice. E: bar graph comparing average responses under various conditions. ***P < 0.001.