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. 2012 Nov 29;8:86. doi: 10.1186/1744-8069-8-86

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Copyright ©2012 Takaishi et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Inhibitory effect of 1,8-cineole in sensory irritation tests in humans. (A and B) 0.5 (wt%) 1,8-cineole did not cause a difference of sensory irritation scores compared with vehicle (n = 10). (C) Sensory irritation caused by 0.2 (wt%) octanol was significantly inhibited by concomitant application of 0.1 (wt%) 1,8-cineole 7 min after application. (D) Total score of sensory irritation by octanol was significantly inhibited by 1,8-cineole. Statistical significance was evaluated using Wilcoxon signed-rank test. *: p < 0.05. n = 11. (E) Sensory irritation caused by 0.5 (wt%) menthol was significantly inhibited by concomitant application of 0.5 (wt%) 1,8-cineole 5 min after application. (F) Total score of sensory irritation by menthol was significantly inhibited by 1,8-cineole. Statistical significance was evaluated using Wilcoxon signed-rank test. *: p < 0.05. n = 11.