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. 2012 Feb 15;32(7):2513–2522. doi: 10.1523/JNEUROSCI.4402-11.2012

Figure 3.

Figure 3.

Dendrodendritic synapses are regulated by both iGluRs and mGluRs. Top, An example dLGN relay neuron in which focal glutamate release (indicated by the black dot) produced a prolonged change in IPSC activity (in TTX: 1 μm). Right, Expanded trace of the period represented by the gray line. Middle, Addition of the mGluR5 antagonist MPEP (50 μm) significantly reduced the duration of IPSC activity but had minimal effect on the magnitude of the initial response. Bottom, Subsequent application of DNQX (20 μm) blocked the initial increase in IPSC activity.