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Windows of opportunity for different therapeutic approaches. (A) Therapy redundant with natural control; (B) Preventive therapy possible due to low malignant cell number and few or no chemoresistant clones; (C) Classic therapy following cancer detection gives a probabilistic outcome as chemoresistant clones in the malignant neoplasm are very likely; (D) Metastatic disease with low probability of curative success; low-dose palliative approaches may extend life.
