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Different examples of intrinsic resistance with clinical relevance.
| Intrinsic resistance mechanisms class | Resistance mechanism | Antibiotics affected | Microorganisms |
|---|---|---|---|
| Inadequate target | PBP5 mutations | Cephalosporins | Enterococcus faecium |
| Inactivating process | L1 beta-lactamase | Carbapenems | Stenotrophomonas maltophilia |
| Impaired permeability | Impermeable cell barrier | Vancomycin | Enterobacteriaceae |
