TABLE 2.
Adverse pregnancy outcomes by maternal depression and antidepressant exposure status
| Pregnancy outcome | Entire cohort (n = 228,876) | Not classified as depressed (n = 195,079) | Depressed pregnant women |
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|---|---|---|---|---|---|
| 0 prescriptions (n = 16,901) | 1∓2 prescriptions (n = 10,700) | >≥ prescriptions (n = 6196) | |||
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| |||||
| Birthweight: 228,813 babies, ga | 3163 ± 587.2 | 3165 ± 587.5 | 3159 ± 577.9 | 3136 ± 588.2 | 3139 ± 598.7 |
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| |||||
| Gestation age, da | 270.7 ± 17.5 | 270.8 ± 17.7 | 270.5 ± 16.5 | 270.6 ± 16.3 | 269.7 ± 16.2 |
|
| |||||
| <32 wk, n (%) | 5491 (2.4) | 4843 (2.5) | 340 (2.0) | 190 (1.8) | 118 (1.9) |
|
| |||||
| 32 to <37 wk, n (%) | 25,481 (11.2) | 21,524 (11.1) | 1939 (11.5) | 1231 (11.5) | 787 (12.7) |
|
| |||||
| ≥37 wk, n (%) | 197,519 (84.4) | 168,377 (86.5) | 14,595 (86.5) | 9271 (86.7) | 5276 (85.4) |
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| Preterm labor: 224,362 women, n (%) | 59,606 (26.6) | 50,094 (26.2) | 4682 (28.1) | 3064 (29.1) | 1766 (29.0) |
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| |||||
| Early preterm labor: 224,362 women, n (%) | 2975 (1.3) | 2542 (1.3) | 209 (1.3) | 129 (1.2) | 95 (1.6) |
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| Delivery method: 228,821 deliveries, n (%) | |||||
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| Normal, spontaneous vaginal delivery | 160,171 (70.0) | 138,009 (70.8) | 11,211 (66.3) | 7027 (65.7) | 3924 (63.3) |
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| Cesarean section delivery | 53,407 (23.3) | 43,951 (22.5) | 4490 (26.6) | 3065 (28.7) | 1901 (30.7) |
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| Assisted | 15,243 (6.7) | 13,070 (6.7) | 1199 (7.1) | 603 (5.7) | 371 (5.9) |
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| Respiratory distress n (%) | 9981 (4.4) | 8358 (4.3) | 774 (4.6) | 516 (4.8) | 333 (5.4) |
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| Convulsions n (%) | 548 (0.2) | 429 (0.2) | 47 (0.3) | 31 (0.3) | 41 (0.7) |
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a
Data are given as mean ± SD.
Hayes. Maternal antidepressants and adverse outcomes. Am J Obstet Gynecol 2012.