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ACF regulates the SOCS3-STAT3-adiponectin pathway in vivo. A, adiponectin mRNA expression in WAT. B and C, total serum adiponectin levels and HMW adiponectin in vehicle- and ACF-treated mice on a HFD. D, qPCR analysis of Socs3 mRNA expression in WAT. E, Western blot analysis of STAT3 activation in WAT after 12 weeks of HFD treatment. **, p < 0.01 compared with vehicle-treated mice (n = 5 mice per group).
