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ACF regulates the SOCS3-STAT3-adiponectin pathway via inhibition of HIF1α in adipocytes in vivo. A, qPCR analysis of Socs3 mRNA expression. B, Western blot analysis of STAT3 activation. C, adiponectin mRNA expression in WAT. D, total adiponectin and HMW adiponectin levels in the sera of vehicle- and ACF-treated mice on a HFD. **, p < 0.01 compared with vehicle-treated mice of the same genotype. (n = 5 mice per group).
