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Activation of MAPK pathways stimulates iPLA2γ-mediated PGE2 production. COS-1 cells were co-transfected with M1 GFP-iPLA2γ WT, COX1, and constitutively active mutants of MEK1, MKK3, or MEKK1 or with empty vector. Untransfected cells are additional controls. PGE2 release was measured 48 h after transfection. *, p < 0.01; **, p < 0.0001 versus vector, three experiments.
