TABLE 2.
Lipid profiles of CE in sebum of control and Fatp4−/−;Tg(IVL-Fatp4) mice
CE was isolated from the hair surface of 7 control mice and 5 Fatp4−/−;Tg(IVL-Fatp4) mice (mutants) and analyzed as ammonium adduct ions by ESI-MS as described under “Experimental Procedures.” Data are indicated as percentage of each lipid species in CE with S.D. and statistical significance indicated. Each species is marked by its m/z (unaccountable for mass defect) on the mass spectrum and its total number (#) of carbons:total number of unsaturated (unsat.) bonds in the fatty acyl moiety of CE.
| m/z ([M + NH4]+) | Species (# carbon:unsat.) | Mean ± S.D. in controls | Mean ± S.D. in mutants |
|---|---|---|---|
| % | |||
| 640 | C16:1 | 2.39 ± 1.80 | 1.66 ± 0.79 |
| 642 | C16:0 | 3.24 ± 1.59 | 3.29 ± 2.43 |
| 666 | C18:2 | 13.93 ± 7.42 | 16.22 ± 4.91 |
| 668 | C18:1 | 36.37 ± 16.42 | 28.73 ± 10.71 |
| 670 | C18:0 | 4.26 ± 1.36 | 2.85 ± 1.47 |
| 696 | C20:1 | 6.41 ± 4.66 | 5.41 ± 1.32 |
| 698 | C20:0 | 5.39 ± 3.49 | 5.67 ± 1.10 |
| 712 | C21:0 | 5.78 ± 3.74 | 4.61 ± 2.16 |
| 724 | C22:1 | 6.62 ± 2.97 | 14.13 ± 6.52a |
| 726 | C22:0 | 3.17 ± 1.42 | 7.07 ± 0.32b |
| 752 | C24:1 | 7.52 ± 4.43 | 7.35 ± 1.86 |
| 754 | C24:0 | 4.92 ± 3.57 | 3.01 ± 1.55 |
a p < 0.05.
b p < 0.001.