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. 2012 Dec 20;288(6):4000–4011. doi: 10.1074/jbc.M112.406777

FIGURE 6.

FIGURE 6.

The in vivo efficacy of SR-3306 in anesthetized rats after 30 min of ischemia and 24 h of reperfusion. SR-3306 was given first as a bolus dose 5 min prior to onset of reperfusion and then administered by constant infusion at a rate of 18 μg/kg/min during the reperfusion phase to yield a final total dose of 5 mg/kg. A, total area of LV volume for three treatment groups: vehicle (DMSO), 40 mg/kg 3-aminobenzamide (3AB) as a positive control, and 5 mg/kg SR-3306. B, infarct size as total LV percent infarct for three treatment groups as described in A. n = 8–9 rats/group.