FIGURE 5.

Curcumin improves some behavioral indices in aged hTau mice. A and B, untreated aged hTau mice performed more poorly than WT and curcumin-treated hTau (hTau + SLN) mice on hidden-platform MWM and did not demonstrate any improvement across trials. C and D, untreated hTau animals also exhibited deficits on visible-platform MWM but did improve across trials. B and D, untreated hTau animals swam more slowly than WT animals on both versions of the MWM and were only partially ameliorated by curcumin treatment. E and F, Y-Maze testing demonstrated that the three groups of animals exhibited similar numbers of total arm entries and rates of spontaneous alternation. G, novel object recognition testing demonstrated significantly less active object exploration in untreated hTau animals than in WT animals. Object exploration in hTau mice was normalized by curcumin treatment. H, untreated hTau mice demonstrated numerically but not statistically significant lower preferences for exploring novel objects. *, p < 0.05 versus wt; **, p < 0.05 versus wt and hTau+SLN.