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. 2012 Dec 13;288(6):4229–4240. doi: 10.1074/jbc.M112.426767

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© 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 6. — Model of COG interactions and COG-mediated vesicle tethering via TMF and the Rabs 1 and 6. A, an interaction map of COG with Rabs, golgins and SNAREs highlighting how subunits form hubs for these transport factor families. Only the interactions of these factors with their respective hub-subunits are shown for clarity. βCOP is added to show its hub-promiscuity, lobe A and B of the complex are represented as dashed red and blue ovals, respectively. B, proposed molecular mechanism of COG mediated tethering. For details see the text. All details are drawn to scale. The TMF and COG drawings shapes are inspired by the EM structures of the golgin p115 (5) and lobe A of yeast COG (65).