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Expression of metabolic master regulators is suppressed in a CHOP-dependent manner. A and B, wild-type or Chop−/− mice were challenged with TM or Velcade for 8 h. Expression of Cebpa, Ppara, Srebf1, and Srebf2 in the liver was assessed by qRT-PCR as in the legend to Fig. 2 (n = three to five animals per group). *, p < 0.05; **, p < 0.01. NT, non-treated.
