TABLE 1.

Statistics for the NMR solution structure of megalin CR10_h residues 1103–1148

NOE distance restraints
Total number	408
Short range	169
Medium range	157
Long range	82
NOE violations
>0.1 Å	21
>0.3 Å	0
Torsion angle restraints (DANGLE)
ϕ	21
ψ	17
Maximal violation >1°	10
Maximal violation >3°	1
Ramachandran plot statistics
Most favorable regions	72.1%
Additional allowed regions	26.3%
Generously allowed regions	1.1%
Disallowed regions	0.5%
r.m.s.d. values
Backbone atoms (all residues)	2.9 ± 1.2 Å
Heavy atoms (all residues)	3.3 ± 1.1 Å
Cys I–VI backbone atoms (Cys-1109–Cys-1143)	0.7 ± 0.2Å
Cys I–VI heavy atoms (Cys-1109–Cys-1143)	1.1 ± 0.2 Å
WHAT-CHECK Z-scores (all residues)
Second generation packing quality	3.4 ± 1.8
Ramachandran plot appearance	−4.2 ± 0.8
χ-1/χ-2 rotamer normality	−4.9 ± 0.5
Backbone conformation	−2.2 ± 0.8
ResProx (70)
All residues	2.05 ± 0.19
Cys I–VI (residues Cys-1109–Cys-1143)	1.68 ± 0.30