Table 1.
DNA Promoter Methylation Status and Gene Expression in CAEP (Squamous Carcinoma) and RAL (Adenocarcinoma) Cell Lines.
Set | Gene Name | CAEP | RAL | ||
Methylation | Expression | Methylation | Expression | ||
TSGs | CDKN2A | M | +++ | U | +++ |
DAPK | U | + | U | ++ | |
FHIT | U | + | U | ++ | |
GSTP1 | U/M | + | U/M | - | |
MGMT | U/M | ++ | U/M | ++ | |
RARβ2 | U/M | + | M | + | |
RASSF1A | U | - | U | - | |
TIMP3 | U | - | U | - | |
Drug resistance | BRCA1 | U | +++ | U | ++ |
COX2 | U | + | U | ++ | |
ERCC1 | U | ++ | U | ++ | |
IGFBP3 | U/M | +++ | U | + | |
RRM1 | U | +++ | U | +++ | |
TUBB3 | U | ++ | U | +++ | |
Stemness | CD133 | M | - | M | + |
OCT4 | M | + | M | + | |
SLUG | U | +++ | U | +++ |
U, unmethylated; M, completely methylated; U/M, partially methylated; +++, highly expressed (>5); ++, medium expressed (>1); +, low expressed (<1); ., not expressed.