Table 1. Associations between CBS −4673C>G and the risk of CHD in 3 separate groups.
| Group | Genotype | Case | Control | P value1 | Logistic Regression |
HWE test2 | |
|---|---|---|---|---|---|---|---|
| OR (95% CI)3 | P value | ||||||
| Shanghai | C/C | 295 (49%) | 273 (41.4%) | 1.00 | |||
| C/G | 255 (42.4%) | 299 (45.3%) | 0.003 | 0.79 (0.62-1.00) | 0.047 | 0.67 | |
| G/G | 52 (8.6%) | 88 (13.3%) | 0.53 (0.36-0.78) | 0.001 | |||
| C | 845 (70.2%) | 845 (64.0%) | 0.001 | 1.00 | |||
| G | 359 (29.8%) | 475 (36.0%) | 0.75 (0.63-0.87) | 0.001 | |||
| Shandong | C/C | 350 (47.6%) | 243 (43.1%) | 1.00 | |||
| C/G | 322 (43.8%) | 244 (43.3%) | 0.011 | 0.91 (0.72-1.15) | 0.44 | 0.23 | |
| G/G | 63 (8.6%) | 77 (13.7%) | 0.57 (0.39-0.82) | 0.0028 | |||
| C | 1 022 (69.5%) | 730 (64.7%) | 0.009 | 1.00 | |||
| G | 448 (30.5%) | 398 (35.3%) | 0.80 (0.68-0.95) | 0.009 | |||
| Jiangsu | C/C | 465 (46.4%) | 430 (41.1%) | 1.00 | |||
| C/G | 430 (42.9%) | 464 (44.4%) | 0.01 | 0.86 (0.71-1.03) | 0.10 | 0.14 | |
| G/G | 108 (10.8%) | 152 (14.5%) | 0.66 (0.50-0.87) | 0.003 | |||
| C | 1 360 (67.8%) | 1 324 (63.3%) | 0.002 | 1.00 | |||
| G | 646 (32.2%) | 768 (36.7%) | 0.82 (0.72-0.93) | 0.002 | |||
| Combined | C/C | 1 110 (47.4%) | 946 (41.7%) | 1.00 | |||
| C/G | 1 007 (43%) | 1 007 (44.4%) | 6.62 × 10−7 | 0.85 (0.75-0.96) | 0.011 | 0.062 | |
| G/G | 223 (9.5%) | 317 (14%) | 0.60 (0.49-0.73) | 1.78 × 10−7 | |||
| C | 3 227 (69.0%) | 2 899 (63.9%) | 2.17 × 10−7 | 1.00 | |||
| G | 1 453 (31.0%) | 1 641 (36.1%) | 0.80 (0.73-0.87) | 2.22 × 10−7 | |||
1Genotype frequencies in case and control participants were compared using χ2 test with 2 degrees of freedom (df).
2P value for Hardy-Weinberg equilibrium test in the control subjects.
3Adjusted for age, sex.