Table 2. Stratification analysis of CBS −4673C>G genotypes according to CHD classification and phenotype. The used controls were the total 2 270 combined controls.

Variable	Case number	P value	Association [OR (95% CI)]1
			CG vs CC	GG vs CC
CHD Classification I 2
Conotruncal defects	386	0.002	0.69 (0.55-0.88)	0.63 (0.44-0.91)
Septation defects	1 652	1.29 × 10−6	0.92 (0.81-1.05)	0.57 (0.46-0.71)
LVOTO	47	0.51	0.69 (0.36-1.30)	0.85 (0.36-2.01)
RVOTO	75	0.98	0.97 (0.59-1.59)	0.92 (0.45-1.91)
APVR	14	0.006	0.08 (0.01-0.66)	0.54 (0.12-2.47)
Complex CHDs	34	0.01	0.30 (0.13-0.71)	0.69 (0.26-1.85)
Other CHDs	132	0.62	0.93 (0.64-1.35)	0.75 (0.42-1.35)
CHD Classification II
Isolated nonsyndromic CHD	2 025	3.2 × 10−7	0.86 (0.75-0.97)	0.58 (0.47-0.70)
Syndromic CHD	315	0.25	0.84 (0.64-1.08)	0.77 (0.53-1.14)
Isolated phenotype
ASD (atrial septal defect)	235	0.0006	0.89 (0.67-1.19)	0.37 (0.22-0.65)
VSD (ventricular septal defect)	1 220	3.18 × 10−5	0.93 (0.80-1.08)	0.58 (0.45-0.74)
TOF (tetralogy of Fallot)	291	0.0016	0.66 (0.50-0.85)	0.59 (0.39-0.89)

¹Adjusted for age, sex;

²Classification described in¹⁶.