Table 4.
Gene induction profiles of the CYP63 P450 family members in response to different xenobiotic groups (Doddapaneni and Yadav 2004; Yadav et al 2006)
| P450 gene | |||||||
|---|---|---|---|---|---|---|---|
| Name of the inducer | CYP63A1 | CYP63A2 | CYP63A3 | CYP63A4 | CYP63C1 | CYP63C2 | CYP63B1 |
| Mono-aromatics: m-Hydroxy benzoic acid, nitrophenol and phenoxy acetic acid | ↑↑ | NR | ↑ | NR | NR | NI | ↑ |
| Poly-aromatics: Naphthalene, phenanthrene, pyrene, 3-methylcholanthrene, p-p′-biphenol and polychlorinated biphenyls) | ↑↑ | ↑↑ | ↑ | ↑↑ | NR | ↑↑* | ↑ |
| Alkyl-substituted aromatics: Dodecylbenzene sulfonate, 1-phenyl dodecane and limonene | ↑↑ | ↑ | NI | ↑↑ | NI | ↑↑ | ↑↑ |
Abbreviations and symbols: ↑↑, high induction; ↑, low induction; NI, negligible induction; NR, no response;
*
CYP63C2 induction was observed only for 1-naphthol and 1,2-benzanthracene.