TABLE 2.

ACE and ACE2 in nebivolol-treated SHRs fed a HSD

	Control	High salt	High salt and nebivolol
ACE mRNA (fold increase in arbitrary units)	1.00 ± 0.06	2.00 ± 0.31*	1.07 ± 0.11#
ACE2 mRNA (fold increase in arbitrary units)	1.06 ± 0.06	0.78 ± 0.09	1.14 ± 0.12#
ACE activity (fmol/ml per min)	4.39 ± 0.61	8.39 ± 1.00*	4.37 ± 0.57#
ACE2 activity (fmol/ml per min)	15.53 ± 2.26	14.63 ± 2.49	18.09 ± 1.56

Results are mean ±SEM. ACE, angiotensin-converting enzyme; ACE2, angiotensin-converting enzyme 2; SHRs, spontaneous hypertensive rats.

^*p < 0.05 vs. control.

^#P< 0.05 vs. untreated salt-loaded group.