Table 1.
Proteins highly expressed or dysregulated in small cell lung cancer (SCLC).
| Protein | Ratio SCLC: NSCLC mean expression |
F-statistic | P | Pathway |
|---|---|---|---|---|
| RB/E2F1 Pathway | ||||
| Rb | 0.39 | 90.69 | < 2.2E-16 | RB/E2F1 pathway (lower SCLC) |
| Rb (Ab2) | 0.61 | 86.38 | < 2.2E-16 | RB/E2F1 pathway (lower SCLC) |
| Rb (Ab2) | 0.60 | 82.93 | < 2.2E-16 | RB/E2F1 pathway (lower SCLC) |
| Rb_pS807/811 | 0.40 | 94.65 | < 2.2E-16 | RB/E2F1 pathway (lower SCLC) |
| E2F1 | 0.49 | 198.66 | < 2.2E-16 | RB/E2F1 pathway (higher SCLC) |
| Cyclin D1 | 0.67 | 75.43 | 2.22E-16 | RB/E2F1 pathway (higher SCLC) |
| Cyclin D1 (Ab2) | 0.51 | 134.55 | < 2.2E-16 | RB/E2F1 pathway (higher SCLC) |
| p16 | 2.13 | 95.65 | < 2.2E-16 | RB/E2F1 pathway (higher SCLC) |
| p21 | 1.78 | 35.08 | 9.02E-09 | RB/E2F1 pathway (higher SCLC) |
| EZH2 | 1.50 | 89.58 | < 2.2E-16 | RB/E2F1 pathway (higher SCLC) |
| Thymidylate synthase | 1.45 | 39.55 | 1.19E-09 | RB/E2F1 pathway (higher SCLC) |
| Cyclin E1 | 1.33 | 23.40 | 2.15E-06 | RB/E2F1 pathway (higher SCLC) |
| Apoptosis | ||||
| PARP1 (cleaved) | 4.25 | 332.36 | < 2.2E-16 | Apoptosis |
| Bcl2 | 4.03 | 357.05 | < 2.2E-16 | Apoptosis |
| BIM | 2.58 | 170.82 | < 2.2E-16 | Apoptosis |
| Bax | 1.64 | 131.27 | < 2.2E-16 | Apoptosis |
| DNA Repair | ||||
| PARP1 (total) | 2.10 | 137.98 | < 2.2E-16 | DNA Repair |
| X53BP1 | 1.99 | 74.93 | 3.33E-16 | DNA Repair |
| DNA.PKcs | 1.69 | 34.35 | 1.26E-08 | DNA Repair |
| ATM | 1.59 | 18.90 | 1.91E-05 | DNA Repair |
| PCNA | 1.56 | 73.60 | 6.66E-16 | DNA Repair |
| ChK2 | 1.51 | 24.89 | 1.05E-06 | DNA Repair |
| PARP1 (total) (Ab2) | 1.44 | 135.67 | < 2.2E-16 | DNA Repair |
| XRCC1 | 1.43 | 72.93 | 7.77E-16 | DNA Repair |
| MSH2 | 1.40 | 31.87 | 3.97E-08 | DNA Repair |
| RAD50 | 1.32 | 22.66 | 3.08E-06 | DNA Repair |
| pATR | 1.31 | 49.13 | 1.71E-11 | DNA Repair |
| ChK1 | 1.29 | 27.63 | 2.87E-07 | DNA Repair |
| X4EBP1_pS65 | 1.26 | 18.06 | 2.90E-05 | DNA Repair |
| BRCA1 | 1.24 | 31.33 | 5.08E-08 | DNA Repair |
| X4EBP1_pST37/46 | 1.23 | 8.95 | 3.02E-03 | DNA Repair |
| pChK1 | 1.22 | 15.91 | 8.45E-05 | DNA Repair |
| TAU | 1.21 | 77.05 | 2.22E-16 | DNA Repair |
| AMPK Pathway | ||||
| LKB1 | 1.42 | 58.82 | 2.70E-13 | AMPK pathway |
| AMPKa_pT172 | 1.41 | 27.96 | 2.46E-07 | AMPK pathway |
| TSC2_pT1462 | 1.16 | 8.27 | 4.33E-03 | AMPK pathway |
| Other SCLC Markers | ||||
| Stathamin | 3.19 | 409.19 | < 2.2E-16 | Mitosis/cell cycle |
| cKit | 9.68 | 237.28 | < 2.2E-16 | Receptor Tyrosine Kinase |
| IGFBP2 | 4.35 | 276.98 | < 2.2E-16 | |
| cMyc_pT58 | 1.35 | 93.38 | < 2.2E-16 | cMyc |
| SMAD3_pS423 | 2.23 | 139.91 | < 2.2E-16 | |
| Src (total) | 1.94 | 90.72 | < 2.2E-16 | |
| SGK_pS78 | 1.54 | 128.32 | < 2.2E-16 |