Table 6.

Safety results that provide a posterior probability of 90% or more of observing a percentage of serious adverse events in the overall sample higher than an acceptable maximum (4%)

Number of serious adverse events	Number of cumulative patients in study
2	13 to 27
3	28 to 44
4	45 to 61
5	62 to 79
6	80 to 98
7	99 to 117
8	118 to 137
9	138 to 157
10	158 to 177
11	178 to 198
12	199 to 218
13	219 to 239
14	240 to 260
15	261 to 281
16	282 to 302
17	303 to 323
18	324 to 345
19	346 to 366
20	367 to 388
21	389 to 410
22	411 to 431
23	432 to 453
24	454 to 475
25	476 to 497
26	498 to 519
27	520 to 541
28	542 to 563
29	564 to 585
30	586 to 608
31	609 to 630
32	631 to 652
33	653 to 674
34	675 to 679