Figure 8.

Schematic representation of the role of A_2AR in the control of BDNF release and microglial proliferation selectively in activated microglia. (A) Constitutive release of BDNF is under the control of PKC (non-treated cells). (B) In the presence of an inflammatory trigger, LPS, the increase in A_2AR density (1) and the subsequent downstream activation of AC-cAMP-PKA (2) prevails over PKC actions, inducing an increase in BDNF release (3), which increases microglial proliferation (4). AC, adenylyl cyclase; cAMP, cyclic AMP; IN, intracellular compartment; PKA, protein kinase A; PKC, protein kinase C.