Table 3.
Comparison of selected factors between the group of ELBW infants with and without wheeze in the last year
| Without wheeze in last year (n=55) | Wheeze in the last year (n=26) | p value | |
|---|---|---|---|
|
Perinatal factors | |||
| Birth weight (g), mean (SD) |
853±139 |
830±159 |
0.8a |
| Gestational age (weeks), mean (SD) |
27.3±2.1 |
27.3±2.6 |
0.9a |
| Female |
37 (67%) |
15 (58%) |
0.5b |
| Length of mechanical ventilation (Me; 25-75th percentile) (days) |
17 (2–48) |
24 (6–39) |
0.8c |
| Length of oxygen therapy (Me; 25-75th percentile) (days) |
44 (13–77) |
55 (34–74) |
0.9c |
| Oxygen therapy at least 28 days |
34 (62%) |
19 (73%) |
0.5b |
| Oxygen therapy at the 36 PMA |
21 (38%) |
10 (38%) |
1.0b |
|
Infancy | |||
| Wheeze in the first 24 months of life |
29 (53%) |
21 (81%) |
0.03b |
| Hospitalization in the first 24 months of life |
25 (45%) |
19 (73%) |
0.03b |
| Immunoprophylaxis with palimivizumab |
8 (15%) |
2 (8%) |
0.5b |
|
Atopy | |||
| Parental history of atopy |
9 (17%) |
5 (22%) |
0.8b |
| Passive smoking |
4 (7%) |
4 (15%) |
0.26b |
| Pets at home |
21 (40%) |
11 (48%) |
0.7b |
| serum tIgE (Me; 25-75th percentile) |
22 (12–68) |
34 (12–73) |
0.3c |
| Absoulte eosinophil count (eos/uL |
230±137 |
338±275 |
0.03a |
| Positive SPT |
4 (7%) |
4 (15%) |
0.26b |
|
Recent status | |||
| Hospitalization in the last year |
2 (4%) |
12 (46%) |
<0.01b |
| Current medications |
11 (20%) |
15 (58%) |
0.002b |
| FEV1 (%) |
80±13 |
83±16 |
0.61a |
| Δ%FEV1 (%) |
1±7 |
16±13 |
0.002a |
| Δ%FEV1 >12% | 0/14 | 4/8 (50%) | 0.01b |
p value for ANOVAa, chi square testb, and Kruskal-Wallis test.
ELBW – extremely low birth weight.