Table 2. Estimation of kidney function for age-matched male GK and non-diabetic wistar rats measured at the end of one month treatment.

Parameters	Animal groups
	Wistar	GK-Saline	GK-Gel
Serum Markers
BUN (mM))	4.6±1.30	7.16±1.37*	4.86±0.58#
Creatinine (µM))	33.8±2.77	43.68±5.22*	32.2±2.39#
UA (µM))	129.8±16.56	181.75±26.33*	122.56±25.16#
Urinary Markers
Volume of urine (ml/day)	15.50	30.00*	18.00#
Color	Light yellow	Dark yellow	Light yellow
pH	6.5	8.5**	6.8##
Microalbumin (mg/L)	8.12	28.24**	9.49##
Creatinine (g/L)	0.92	2.69	1.07
ACR	7.96	10.50**	8.11##

Serum parameters were measured under fed condition. Urinary parameters were measured after the collection of urine for 24 hrs. BUN: blood urea nitrogen, UA: uric acid, ACR: albumin to creatinine ratio.

^*, p<0.05; **, p<0.01 versus age-matched wistar group.

#, p<0.05; ##, p<0.01 versus GK-saline group as determined by student t-test. values are given as mean ± SD for the group of 5 animals each.