. 2013 Feb 8;8(2):e56213. doi: 10.1371/journal.pone.0056213

Table 3. Risk prediction of allele combination of examined polymorphisms for lung cancer before and after adjusting for confounding factors.

Allele combination^†	Patients	Controls	P_Sim ^*	OR; 95% CI; P	OR; 95% CI; P^**
Arg-Arg-Thr	38.77%	42.0%	0.145	Reference	Reference
Trp-Arg-Thr	29.94%	30.91%	0.411	1.03; 0.86–1.25; 0.734	0.99; 0.73–1.36; 0.965
Trp-Arg-Met	2.07%	1.92%	0.261	1.12; 0.54–2.32; 0.759	1.26; 0.48–3.28; 0.64
Arg-Gln-Thr	24.2%	22.21%	0.217	1.18; 0.96–1.45; 0.121	0.88; 0.63–1.22; 0.444
Arg-Arg-Met	2.54%	1.66%	0.079	1.73; 0.84–3.58; 0.139	2.01; 0.61–6.58; 0.252
Arg-Gln-Met	2.48%	0.9%	0.001	3.01; 1.16–7.77; 0.023	3.89; 1.45–8.1; <0.001

Abbreviations: OR, odds ratio; 95% CI, 95% confidence interval. * Simulated P values. ** Calculation was performed by adjusting for age, gender, smoking and drinking. ^† Alleles were in order of Arg194Trp, Arg399Gln and Thr241Met polymorphisms.