Figure 15. FTS loaded core/shell fiber structures inhibit growth or induce cell death of glioblastoma cells by a gradient effect and dose-dependent manner. U87 cells were plated at a density of 8x103 cells/well in a 24-well plate in tetraplicate (n = 2). One day after plating, control fibers (not loaded with FTS), slow or fast FTS release fibers were added to each well (2 fibers, each with a length of 1 cm, as described in the materials and methods). (A) Images taken after 5 d of incubation with FTS fibers, in locations which are near and distant to the fiber (magnification × 100). (B) A single well edge to edge panoramic view shows a gradiential increase in the cell concentration with the increase in the distance from a slow release fiber (magnification × 100, cells were counted using an image analysis software). (C) Images were taken after 7 d of incubation with FTS fibers; the control fiber well presents high cell viability while the well containing the fast FTS fiber exhibited cell death (magnification × 100). Note that the dark shape is the actual fiber.¹³³