Table 1. Structural characteristics of the ceftazidime-loaded porous matrix70.
| Formulation | O:A | Drug loading* (w/w) | Polymer content in the organic phase**(w/v) | Polymer MW (KDa) | Surfactant** | Freeze-dried emulsion | ||
|---|---|---|---|---|---|---|---|---|
| |
|
|
|
|
|
|
Porosity (%) |
Pore diameter (μm) |
| Basic Formulations |
(1) Reference |
6:1 |
|
15% |
100 |
None |
68 |
1.5 ± 0.6 |
| (2) High O:A |
12:1 |
5% |
15% |
100 |
None |
45 |
1.6 ± 0.4 |
|
| (3) High polymer content |
6:1 |
5% |
20% |
100 |
None |
22 |
1.2 ± 0.9 |
|
| (4) High polymer MW |
6:1 |
5% |
15% |
240 |
None |
16 |
0.5 ± 0.4 |
|
| Formulations with Surfactants | (5) BSA1: ref., stabilized with BSA |
6:1 |
5% |
15% |
83 |
BSA (1% w/v in the aqueous phase) |
63 |
1.4 ± 0.3 |
| (6) BSA2: high O:A, stabilized with BSA |
12:1 |
5% |
15% |
83 |
BSA (1% w/v in the aqueous phase) |
35 |
1.4 ± 0.3 |
|
| (7) SPAN: high O:A, stabilized with Span | 12:1 | 5% | 15% | 83 | Span80 (1% w/v in the organic phase) | 45 | 1.1 ± 0.3 | |
*
Relative to the polymer weight, **relative to the liquid phase volume (organic or aqueous)