TABLE 3.
Sensitivity, specificity, and predictive values of different primers for detection of CMV pp65 antigenemiaa
| Primer (n)b | Prevalence of antigenemiac | Proportion of samples positive by PCRc | Sensitivityd | Specificitye | Positive predictive valuef | Negative predictive valueg |
|---|---|---|---|---|---|---|
| UL125 (1,875) | 150 (8.0) | 282 (15.0) | 86/150 (57.3) | 1,529/1,725 (88.8) | 86/282 (30.5) | 1,529/1,593 (96.0) |
| UL126 (1,888) | 150 (7.9) | 369 (19.5) | 111/150 (74.0) | 1,480/1,738 (85.2) | 111/369 (29.1) | 1,480/1,519 (97.4) |
| UL55/UL123 (1,902) | 151 (7.9) | 244 (12.8) | 122/151 (80.1) | 1,629/1,751 (93.0) | 122/244 (50.0) | 1,629/1,658 (98.3) |
| UL55/UL123 (1,582) (not on antivirals) | 64 (4.0) | 116 (7.3) | 48/64 (75.0) | 1,450/1,518 (95.5) | 48/116 (41.4) | 1,450/1,466 (98.9) |
Only samples with sufficient numbers of cells to perform the antigenemia assay were included. The numbers vary slightly because not all tests were performed in each series.
n, number of samples used for analysis.
Values are numbers of samples. Values in parentheses are percentages.
Each value is the number of samples positive by both PCR and pp65 antigenemia assays/number of samples positive by pp65 antigenemia assay. Values in parentheses are percentages.
Each value is the number of samples negative by both PCR and pp65 antigenemia assays/number of samples negative by pp65 antigenemia assay. Values in parentheses are percentages.
Each value is the number of samples positive by PCR and pp65 antigenemia assays/number of samples positive by PCR assay. Values in parentheses are percentages.
Each value is the number of samples negative by PCR and pp65 antigenemia assays/number of samples negative by PCR assay. Values in parentheses are percentages.