Table 2. Characteristics of patients in the pooled analysis (N = 2417).

Study/year	Treatment arm	No.ofpatients	FemaleSex (%)	Medianage, y	History of smoking,%	KRAS mutation,n (%)	EGFR mutation,n (%)
Lynch T.J. et al. 2009	Combination	25	56	62	84	NR	NR
	Single	25	48	64	80	NR	NR
Bennouna J. et al. 2010	Combination	66	NR	59	80	NR	NR
	Single	67	NR	60	82	NR	NR
HerBst, Roy S. et al. 2011	Combination	319	46	64.8	89	48 (25)	33(32)
	Single	317	46	65	90	38 (21)	43(42)
Sequist L.V. et al. 2011	Combination	84	39	64	80	10 (17)	38(52)
	Single	83	41	62	78	5 (10)	59 (40)
Spigel D.R. et al. 2011	Combination	112	44	65	NR	5 (4.5)	22(19.6)
	Single	56	53	65	NR	6(10.7)	14(25)
Ramalingam S.S. et al. 2011	Combination(weekly)	57	32	63	86	16 (27)	NR
	Combination (every 3 weekly)	57	33	62	91	12(36)	NR
	Single	57	35	62	84	8 (19)	NR
Scagliotti G.V. et al 2011	Combination	480	38.1	61	80	NR	28(5.8)
	Single	480	40.8	61	81.3	NR	30(6.3)
Witta S.E.et al. 2012	Combination	67	42	66	84	4(9)	18(60)
	Single	65	34	67	83	7(21)	11(38)