Figure 3. Cerebral parenchymal β-amyloid deposits are markedly attenuated in PSAPP mice after oral ferulic acid (FA) treatment.

Representative photomicrographs were obtained from PSAPP mice treated with vehicle (PSAPP-V) or with FA (PSAPP-FA) for 6 months starting at 6 months of age (mouse age at sacrifice = 12 months). 4G8 immunohistochemistry is depicted, revealing cerebral β-amyloid deposits in PSAPP-V and PSAPP-TA mice. Brain regions shown include: cingulate cortex (CC, top), hippocampus (H, middle), and entorhinal cortex (EC, bottom). Middle H panels are higher magnification images from insets in the upper H panels. Scale bars denote 250 µm (upper) and 50 µm (lower).