Skip to main content
. 2013 Feb 8;8(2):e55774. doi: 10.1371/journal.pone.0055774

Figure 8. Oral treatment with ferulic acid (FA) attenuates reactive astrocytosis in PSAPP mice.

Figure 8

Data were obtained from PSAPP mice treated with vehicle (PSAPP-V, n = 12) or with FA (PSAPP-FA, n = 12) for 6 months beginning at 6 months of age. (A) Representative photomicrographs of glial fibrillary acidic protein (GFAP) immunohistochemistry for β-amyloid deposit-associated astrocytosis are shown from PSAPP-V and PSAPP-FA mice at 12 months of age. Brain regions depicted include: cingulate cortex (CC, top), hippocampus (H, middle), and entorhinal cortex (EC, bottom). Scale bar denotes 50 µm. (B) Quantitative image analysis for GFAP burden is shown for each brain region indicated on the x-axis. All statistical comparisons are between PSAPP-V and PSAPP-FA mice.