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. Author manuscript; available in PMC: 2014 Sep 26.
Published in final edited form as: Neuroscience. 2012 Sep 25;249:31–42. doi: 10.1016/j.neuroscience.2012.09.045

Figure 3. Elevated plus maze.

Figure 3

The open to total ratio (OTR) for time (time in open arms/(time in open + closed arms)) is presented, a higher OTR is indicative of decreased anxiety-like behavior. A) In CON groups, female Nrg1Tn rats spent significantly more time in the open arms than female WT rats (**p<0.01) while CON male Nrg1Tn rats tended to spend less time in the open arms than CON WT rats (#p<0.09). A slight effect of adolescent CVS was found such that WT CVS-treated females tended to spend more time in the open arms than WT CON females (+p<0.08). Female Nrg1Tn rats were resistant to adolescent CVS. B) In both WT and Nrg1Tn CON rats, a sex difference was detected. In CON WT animals, males spent more time in the open arms than females (*p<0.04), whereas in CON Nrg1Tn animals, males spent less time in the open arms than females (*p<0.05). CVS exposure eliminated sex differences in both genotypes. Bars represent mean OTR ± SEM.