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EYA subcellular localization and functions. The EYAs are intrinsically cytoplasmic proteins. Upon interaction with the SIX proteins (with the exception of SIX3) they are translocated into the nucleus where they are localized on DNA via the homeodomain of the SIX proteins, and convert the SIX proteins into transcriptional activators. The proposed cellular functions for cytoplasmic and nuclear EYA are shown in the gray boxes and discussed in the text
