Table 3.

Phenotypes of Eya mutant mice

Mouse mutant	Phenotype	References
Eya1−/−	Die at birth; craniofacial and skeletal defects; ear malformation; dysmorphic/absent kidneys; thymus and parathyroid agenesis; thyroid hypoplasia; open eyelids; hypoplastic lungs	[59, 60, 155]
Eya2−/−	No external phenotype; viable and fertile	[156]
Eya1−/− Eya2−/+	No diaphram; severe limb muscle hypoplasia	[156]
Eya3−/−	Viable and fertile with no external phenotype; reduced body length	[108]
Eya4−/−	Die shortly after birth; abnormal ear development and hearing deficiency; males sterile or reduced fertility	[105]