Table 4.

EYA and human disease

Disease	Gene	Type of misregulation	References
Branchiootorenal syndrome	EYA1	Loss of function mutations	[87, 95]
Otofaciocervical syndrome	EYA1	Loss of function mutations	[97]
Cardiofacial syndrome	EYA1	Loss of function mutations	[107]
Congenital cataract	EYA1	Loss of function mutations	[47]
Wilms’ tumor	EYA1	Overexpression	[137]
EBV-negative gastric cancer	EYA1	Frequent methylation	[138]
Late-onset deafness	EYA4	Loss of function mutations	[99]
Dilated cardiomyopathy	EYA4	Deletion	[106]
Esophageal adenocarcinoma	EYA4	Frequent methylation (overexpression)	[128]
Colon cancer	EYA4	Overexpression	[130]
Colorectal cancer	EYA4	Overexpression	[131]
Colorectal cancer	EYA2	Silencing methylation	[139]
Epithelial ovarian cancer	EYA2	Overexpression	[133]
Lung adenocarcinoma	EYA2	Overexpression	[134]
Pancreatic ductal adenocarcinoma	EYA3	Frequent deletion	[140]