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. 2013 Jan 23;110(6):2252–2257. doi: 10.1073/pnas.1222047110

Fig. 4.

Fig. 4.

Transfer of IFN-γ–competent NK cells improves Salmonella control in Rag2−/−γc−/− mice: (A–D) 1 × 106 purified in vitro–activated NK cells or PBS were injected i.v. into naïve Rag2−/−γc−/− mice on day 5 and 6 after in vitro culture. Mice were i.v. infected with 200 cfu BRD509 24 h later. Some mice were injected twice weekly i.p. with antibodies against mouse Thy1 (30-H12). Bacterial numbers in spleen (A) and liver (B) were assessed, and serum samples were analyzed for IFN-γ by cytometric bead array (C) at 23 d after infection. In separate experiments, survival (D) was assessed. Data are representative of at least two independent experiments. Survival plots of 10 mice (D) or individual pooled data points (A–C) are shown. Statistical analyzes: one-way ANOVA followed by Bonferroni multiple comparison test (A–C); log-rank (Mantel-Cox) test (D). ***P < 0.001, **P < 0.01.