Fig. 5.

NK cells are not essential for control of primary infection when other cell types are present. (A) B6 and CD1d^−/− mice were injected i.p. with PBS or antibodies against mouse NK1.1 (PK136) and infected i.v. with 200 cfu S. Typhimurium BRD509 48 h later. Injection of depleting antibodies or PBS was continued twice weekly for 3 wk. Splenic NK cell numbers (A) and bacterial counts in spleen (B) and liver (C) were determined on day 21 after infection. Data are representative of two pooled independent experiments with seven to eight mice per group. Statistical analyses: paired Student t test (A). ***P < 0.001, **P < 0.01.