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(A) DAH7PS catalyzes the first step of the shikimate pathway, the condensation of PEP and E4P to give 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAH7P), for the biosynthesis of the aromatic amino acids. (B) A superposition of the barrels of the open Tyr-free (PDB ID code 1RZM, green) and closed Tyr-bound (PDB ID code 3PG9, purple) conformations of TmaDAH7PS showing the rearrangement of the ACT domains in the presence of Tyr.
