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. 2013 Jan 22;110(6):2181–2186. doi: 10.1073/pnas.1222377110

Fig. 4.

Fig. 4.

Effect of dauer formation mutants on down-regulation of lag-2 transcription. (A) Schematic representation of the major signaling pathways that regulate the dauer formation decision (1). Boxes indicate active components under the indicated conditions. (B) Percentage of larvae expressing lag-2p::yfp in P6.p at 25 °C (n = 13–37). (C) Percentage of larvae expressing lag-2p::yfp in P6.p at 25 °C (“+” indicates exogenous pheromone was added to create an unfavorable environment condition as in A, Right). (Left) n = 13–34. (Right) Laser ablation (abl) of the gonad (n = 8) compared with mock-ablated (mock) larvae (n = 7). (D) Percentage of larvae expressing lag-2p::yfp in P6.p at 25 °C (“+” indicates exogenous pheromone was present; n = 23–44). *P < 0.01 (Fisher’s exact test). NS, not significant.