Table 2.
Biofilm formation and antimicrobial resistance in clinical isolates
|
A. baumannii |
E. coli |
K. pneumoniae |
P. aeruginosa |
S. aureus |
||||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
n=53 |
n=39 |
n=54 |
n=36 |
n=23 |
||||||
% MDRa |
86.7%; 46/53 |
79.5%; 31/39 |
100% |
77.7%; 28/36 |
65.2%; 15/23 |
||||||
Antimicrobial | %b | %Biofilm Production | % | % Biofilm Production | % | % Biofilm Production | % | % Biofilm Production | % | % Biofilm Production | |
Aminoglycosides |
|
|
|
|
|
|
|
|
|
|
|
Amikacin |
R |
67 |
65 |
10 |
33 |
20 |
83 |
25 |
67 |
ND |
ND |
S |
33 |
47 |
90 |
15 |
80 |
50 |
75 |
81 |
ND |
ND |
|
Gentamicin |
R |
90 |
89 |
47 |
14 |
93 |
79 |
39 |
75 |
3 |
100 |
S |
10 |
67 |
53 |
19 |
7 |
71 |
61 |
59 |
97 |
90 |
|
Tobramycin |
R |
70 |
81 |
53 |
19 |
53 |
81 |
23 |
90 |
ND |
ND |
S |
30 |
33 |
47 |
14 |
47 |
64 |
77 |
78 |
ND |
ND |
|
Ansamycins |
|
|
|
|
|
|
|
|
|
|
|
Rifampin |
R |
ND |
ND |
ND |
ND |
ND |
ND |
ND |
ND |
0 |
92 |
S |
ND |
ND |
ND |
ND |
ND |
ND |
ND |
ND |
100 |
78 |
|
Cephalosporins |
|
|
|
|
|
|
|
|
|
|
|
Cefazolin |
R |
ND |
ND |
93 |
14 |
90 |
67 |
100 |
80 |
69 |
99 |
S |
ND |
ND |
7 |
50 |
10 |
0 |
0 |
0 |
31 |
50 |
|
Cefepime |
R |
ND |
ND |
77 |
9 |
93 |
82 |
63 |
79 |
ND |
ND |
S |
ND |
ND |
23 |
43 |
7 |
56 |
37 |
82 |
ND |
ND |
|
Cefoxitin |
R |
ND |
ND |
10 |
67 |
13 |
100 |
100 |
80 |
74 |
95 |
S |
ND |
ND |
90 |
11 |
87 |
65 |
0 |
0 |
26 |
60 |
|
Cefotaxime |
R |
80 |
63 |
ND |
ND |
93 |
68 |
ND |
ND |
ND |
ND |
S |
20 |
50 |
ND |
ND |
7 |
100 |
ND |
ND |
ND |
ND |
|
Ceftazidime |
R |
53 |
44 |
77 |
13 |
97 |
86 |
67 |
90 |
ND |
ND |
S |
47 |
93 |
23 |
29 |
3 |
33 |
33 |
60 |
ND |
ND |
|
Ceftriaxone |
R |
ND |
ND |
80 |
13 |
87 |
73 |
100 |
80 |
ND |
ND |
S |
ND |
ND |
20 |
33 |
13 |
69 |
0 |
0 |
ND |
ND |
|
Carbepenems |
|
|
|
|
|
|
|
|
|
|
|
Imipenem |
R |
67 |
85 |
0 |
0 |
0 |
0 |
75 |
86 |
ND |
ND |
S |
33 |
30 |
100 |
17 |
100 |
70 |
25 |
95 |
ND |
ND |
|
Meropenem |
R |
67 |
85 |
0 |
0 |
0 |
0 |
58 |
78 |
ND |
ND |
S |
33 |
30 |
100 |
17 |
100 |
70 |
42 |
82 |
ND |
ND |
|
Flouroquinolones |
|
|
|
|
|
|
|
|
|
|
|
Ciprofloxacin |
R |
90 |
85 |
83 |
12 |
63 |
79 |
75 |
80 |
ND |
ND |
S |
10 |
33 |
17 |
40 |
37 |
45 |
25 |
100 |
ND |
ND |
|
Levofloxacin |
R |
57 |
71 |
83 |
12 |
50 |
80 |
80 |
92 |
50 |
93 |
S |
43 |
92 |
17 |
40 |
50 |
60 |
20 |
50 |
50 |
80 |
|
Penicillins |
|
|
|
|
|
|
|
|
|
|
|
Ampicillin |
R |
100 |
67 |
97 |
17 |
100 |
70 |
100 |
80 |
100 |
100 |
|
S |
0 |
0 |
3 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Aztreonam |
R |
100 |
67 |
73 |
9 |
97 |
90 |
73 |
73 |
ND |
ND |
S |
0 |
0 |
27 |
38 |
3 |
100 |
27 |
100 |
ND |
ND |
|
Oxacillin |
R |
ND |
ND |
ND |
ND |
ND |
ND |
ND |
ND |
83 |
92 |
S |
ND |
ND |
ND |
ND |
ND |
ND |
ND |
ND |
17 |
60 |
|
Piperacillin |
R |
93 |
71 |
13 |
0 |
30 |
78 |
67 |
75 |
ND |
ND |
S |
7 |
100 |
87 |
19 |
60 |
61 |
33 |
90 |
ND |
ND |
|
Tetracyclines |
|
|
|
|
|
|
|
|
|
|
|
Tetracycline |
R |
80 |
71 |
67 |
20 |
63 |
58 |
ND |
ND |
20 |
83 |
|
S |
20 |
50 |
33 |
10 |
37 |
91 |
ND |
ND |
80 |
88 |
Sulfonamides |
|
|
|
|
|
|
|
|
|
|
|
Trimeth-Sulfameth |
R |
90 |
78 |
77 |
17 |
73 |
86 |
100 |
80 |
0 |
0 |
S | 10 | 50 | 23 | 14 | 27 | 50 | 0 | 0 | 1000 | 87 |
a A multidrug-resistant (MDR) organism was defined as any extented spectrum-lactamase (ESBL) producing bacteria, or if resistant to all tested antimicrobials on 3 or more classes of antimicrobial agent.
b %; indicates the percentage of isolates resistant (R) or sensitive (S) to each antimicrobial agent. Antimicrobial suceptibilities were determined using BD Phoenix™ automated microbiology system and are reflective of clinical breakpoints.