Table 3.
BMD values for the individual genotypes for each single SNP
| SNP | WT | HET | HOMO | p valuea | p valueb | p valuec |
|---|---|---|---|---|---|---|
| Tyr315Cys | AA | AG | GG | – | – | – |
| N | 885 | 24 | – | – | – | – |
| BMD TH (g/cm2) | 0.84 (0.15) | 0.79 (0.17) | – | – | – | 0.5467 |
| BMD LS (g/cm2) | 0.93 (0.17) | 0.85 (0.17) | – | – | – | <0.001 |
| BMD FN (g/cm2) | 0.69 (0.13) | 0.66 (0.15) | – | – | – | 0.9356 |
| Female | AA | AG | GG | – | – | – |
| N | 667 | 19 | – | – | – | – |
| BMD TH (g/cm2) | 0.80 (0.13) | 0.76 (0.17) | – | – | – | 0.8819 |
| BMD LS (g/cm2) | 0.91 (0.17) | 0.82 (0.16) | – | – | – | 0.0124 |
| – | BMD FN (g/cm2) | 0.63 (0.16) | – | – | – | 0.6703 |
| Male | AA | AG | GG | – | – | – |
| N | 225 | 5 | – | – | – | – |
| BMD TH (g/cm2) | 0.95 (0.15) | 0.92 (0.09) | – | – | – | 0.9546 |
| BMD LS (g/cm2) | 0.98 (0.17) | 0.96 (0.17) | – | – | – | 0.0145 |
| BMD FN (g/cm2) | 0.76 (0.13) | 0.73 (0.06) | – | – | – | 0.9404 |
| Ser242Gly | AA | AG | GG | – | – | – |
| N | 718 | 169 | 10 | – | – | – |
| BMD TH (g/cm2) | 0.84 (0.15) | 0.82 (0.15) | 0.85 (0.17) | 0.8075 | 0.5728 | 0.6127 |
| BMD LS (g/cm2) | 0.92 (0.17) | 0.92 (0.15) | 1.11 (0.35) | 0.3448 | 0.0045 | 0.4189 |
| BMD FN (g/cm2) | 0.69 (0.13) | 0.68 (0.13 | 0.70 (0.11) | 0.7087 | 0.8949 | 0.6131 |
| Female | AA | AG | GG | – | – | – |
| N | 549 | 125 | 6 | – | – | – |
| BMD TH (g/cm2) | 0.80 (0.13) | 0.79 (0.13) | 0.78 (0.17) | 0.6206 | 0.5859 | 0.6883 |
| BMD LS (g/cm2) | 0.91 (0.16) | 0.91 (0.15) | 1.09 (0.36) | 0.5507 | 0.0202 | 0.9283 |
| BMD FN (g/cm2) | 0.67 (0.12) | 0.65 (0.11) | 0.65 (0.10) | 0.5907 | 0.8804 | 0.5889 |
| Male | AA | AG | GG | – | – | – |
| N | 175 | 47 | 4 | – | – | – |
| BMD TH (g/cm2) | 0.95 (0.15) | 0.93 (0.17) | 0.97 (0.12) | 0.8178 | 0.8931 | 0.8280 |
| BMD LS (g/cm2) | 0.98 (0.16) | 0.98 (0.16) | 1.14 (0.38) | 0.6539 | 0.0510 | 0.9131 |
| BMD FN (g/cm2) | 0.76 (0.13) | 0.74 (0.14) | 0.77 (0.10) | 0.8568 | 0.9493 | 0.8231 |
p values are shown for PLINK association analysis for the bone mineral density (BMD) parameters adjusted for age, BMI and sex. Numbers are mean (SD)
WT wild-type; HET heterozygote; HOMO homozygote; TH total hip; LS lumbar spine; FN femoral neck
aAdjusted for age, BMI, and sex: additive model
bAdjusted for age, BMI, and sex: recessive model
cAdjusted for age, BMI, and sex: dominant model
.