Fig. 3.

Effect of pretreatment with CaCl₂ (200 nmol/site, i.t.) on the antinociception induced by inosine. Mice were pretreated with an intrathecal injection of CaCl₂ 15 min before intraperitoneal administration of inosine or subcutaneous administration of morphine. Values are expressed as the mean + SEM. The asterisks denote significance levels when compared with vehicle group (one-way ANOVA followed by Newman–Keuls test). **P < 0.01, ***P < 0.001. ^#P < 0.01 indicates the significance levels when comparing the inosine and morphine treatments with their respective vehicle group