Table 4.

BMD values for the individual genotypes for each single SNP

SNP	WT	HET	HOMO	p valuea
Woman
Leu46Pro	TT	TC	CC
N	569	100	11
BMD TH (g/cm2)	0.79 (0.13)	0.81 (0.14)	0.83 (0.13)	0.054
BMD LS (g/cm2)	0.90 (0.16)	0.93 (0.17)	0.99 (0.17)	0.026
BMD FN (g/cm2)	0.66 (0.12)	0.68 (0.12)	0.70 (0.14)	0.013
Arg312Ser	GG	GC	CC
N	398	236	41
BMD TH (g/cm2)	0.80 (0.13)	0.81 (0.14)	0.76 (0.13)	0.073
BMD LS (g/cm2)	0.91 (0.17)	0.91 (0.16)	0.90 (0.18)	0.926
BMD FN (g/cm2)	0.66 (0.11)	0.67 (0.12)	0.65 (0.11)	0.352
Arg334Cys	GG	GA	AA
N	483	157	23
BMD TH (g/cm2)	0.80 (0.13)	0.80 (0.14)	0.78 (0.13)	0.844
BMD LS (g/cm2)	0.91 (0.17)	0.91 (0.17)	0.90 (0.16)	0.947
BMD FN (g/cm2)	0.67 (0.11)	0.66 (0.12)	0.64 (0.12)	0.843
Men
Leu46Pro	TT	TC	CC
N	188	39	3
BMD TH (g/cm2)	0.94 (0.15)	0.98 (0.15)	0.90 (0.12)	0.479
BMD LS (g/cm2)	0.98 (0.17)	1.00 (0.17)	0.88 (0.13)	0.429
BMD FN (g/cm2)	0.76 (0.13)	0.77 (0.13)	0.71 (0.10)	0.775
Arg312Ser	GG	GC	CC
N	145	67	15
BMD TH (g/cm2)	0.95 (0.16)	0.96 (0.14)	0.88 (0.16)	0.732
BMD LS (g/cm2)	0.97 (0.16)	1.00 (0.19)	0.97 (0.16)	0.462
BMD FN (g/cm2)	0.76 (0.13)	0.76 (0.13)	0.73 (0.14)	0.960
Arg334Cys	GG	GA	AA
N	153	63	8
BMD TH (g/cm2)	0.95 (0.14)	0.93 (0.17)	1.04 (0.16)	0.158
BMD LS (g/cm2)	0.99 (0.17)	0.95 (0.16)	1.00 (0.17)	0.272
BMD FN (g/cm2)	0.76 (0.13)	0.75 (0.14)	0.79 (0.16)	0.863

p values are shown for statistical analysis of covariance (ANCOVA) for the bone mineral density (BMD) parameters adjusted for age and BMI. Numbers are means (SD)

LS lumbar spine, FN femoral neck, TH total hip

^aAdjusted for age and BMI