Table 4.
Results of univariate analysis of clinicopathological parameters and the expression levels of six mTOR related biomarkers in relations to disease specific survival, overall survival and disease progression. Pten: phosphatase and tensine homologue; p27: p27kip; phos Akt: phoporylated Akt; phos S6: phosphorylated S6 protein; 4E-BP1: eukaryotic translation initiation factor 4E-binding protein-1. NS: not significant.
| Univariate Analysis | |||
|---|---|---|---|
| Outcome | |||
| DSS | OS | Progression | |
| Clinicopathological Parameters | |||
| pT | p=0.080 | p=0.083 | p=0.061 |
| TNM stage grouping | p=0.007 | p=0.024 | p=0.039 |
| Organ confined disease status | p=0.016 | p=0.021 | p=0.010 |
| Lymph node status | p=0.050 | p=NS | p=0.010 |
| Lymphovascular invasion | p=0.020 | p=0.002 | p=0.060 |
| Divergent aggressive histology | p=0.005 | p=0.029 | p=0.031 |
| Concomitant CIS | p=NS | p=0.008 | p=NS |
| mTOR Markers | |||
| Pten | p=NS | p=NS | p=NS |
| Phos Akt | p=NS | p=NS | p=NS |
| Phos S6 | p=0.001 | p=0.01 | p=0.05 |
| 4 EBP-1 | p=NS | p=NS | p=NS |
| c-Myc | p=NS | p=NS | p=0.01 |
| P27 | p=NS | p=NS | p=NS |