Table 5.

Two multivariate cox-regression analysis models correlating clinicopathological parameters and expression levels of mTOR related biomarkers with disease specific survival, overall survival and disease progression. Model 1 includes TNM stage grouping while Model 2 includes organ confined disease status and lymph node status as a substitute. Both models include aggressive histology concomitant CIS; Phos S6 and c-myc. DSS: disease specific survival, OS: overall survival; phos Akt: phosphorylated Akt; phos S6: phosphorylated S6 protein. HR: Hazard ratio. 95%CI: 95% confidence interval. NS: not significant.

Multivariate analysis – MODEL 1
	Outcome
	DSS	OS	Progression
phos S6	p=0.03	p=NS	p=NS
	HR: -.19
	95%CI: -.37 to -.01
c-Myc	p=NS	p=NS	p=0.02
			HR: -.38
			95%CI: -.70 to -.06
TNM stage grouping	p=0.004	p=NS	p=0.01
	HR: .11		HR: .10
	95%CI: .03 to .18		95%CI: .02 to .18
Divergent aggressive histology	p=NS	p=NS	p=NS
Concomitant CIS	p=NS	p=NS	p=NS
Multivariate analysis – MODEL 2
	Outcome
	DSS	OS	Progression
phos S6	p=0.03	p=NS	p=NS
	HR: -.21
	95%CI: -.40 to -.02
c-Myc	p=NS	p=NS	p=0.03
			HR: -.34
			95%CI: -.67 to -.02
Organ confined disease status	p=NS	p=NS	p=0.03
			HR: .22
			95%CI: .02 to .42
Lymph node status	p=NS	p=NS	p=NS
Divergent aggressive histology	p=NS	p=NS	p=NS
Concomitant CIS	p=NS	p=NS	p=NS