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Degradation of radiolabeled c-di-GMP (*c-di-GMP) in the presence of EAL domain resistant c-di-GMP analogs. (a) PEI-cellulose TLC showing degradation of *c-di-GMP to pGpG by CC3396 over time. (b) Degradation of *c-di-GMP in the presence of unlabeled c-di-GMP. (c) Fraction of pGpG formed from degradation of *c-di-GMP by CC3369 over time in the presence of unlabeled c-di-AMP, dithiophosphate, and methylphosphonate analogs.
