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. Author manuscript; available in PMC: 2013 Nov 27.
Published in final edited form as: Biochemistry. 2012 Nov 14;51(47):9488–9500. doi: 10.1021/bi301069r

FIGURE 10.

FIGURE 10

Orientations of CYP3A4 and holo/apo b5 in membranes. The angle between CYP3A4 heme (red) plane and the membrane slab (blue) was adjusted to 58°, a middle value between 38° and 78° according to (60). Holo and apo b5 linker domain conformation was made flexible according to (50), as well as the human and rabbit cyt b5 NMR structure (PDB: 2I96). CYP3A4 is light purple; holo b5 is green; apo b5 is cyan. (A) Holo b5-CYP3A4 interaction model position relative to the membrane; (B) Apo b5-CYP3A4 interaction model position relative to the membrane.