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Effect of CPR/CYP ratio on formation of 6β-hydroxytestosterone by CYP3A4 and its mutations. Reactions were carried out using varying concentrations of CPR, constant ratio of CYP3A4 (40 pmol) / cyt b5 (40 pmol) for 10 min in 200 uL reaction volume. Each point represents the mean ± S.D. (n=3).
